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KMID : 0043319960190050348
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Archives of Pharmacal Research
1996 Volume.19 No. 5 p.348 ~ p.352
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The Effect of Aspalatone, a New Antithrombotic Agent, on the Specific Activity of Antioxidant Enzyme in the Rat Blood
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Kim Chin
Koo Chang-Hui
Choi Dong-Young
Cho Yong-Joon
Choi Jae-Ho
Im Doo-Hyeon
Jhoo Wang-Kee
Kim Hyoung-Chun
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Abstract
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The antioxidant efficacy of aspalatone, a new antithrombotic agent, has been recognized in the neurotoxic model and in the cardiotoxic model in proliminary studies. We examined the specific activity of antiosidnat enzyme in the rat blood following administrations of aspirin, maltol, aspirin together with maltol, salicylmaltol (major metabolite of aspalatone) and aspalatone, respectively. Our assessment showed that salicylmaltol, maltol, aspalatone enhanced antiperoxidative activity. In addition, neither aspirin nor combination of aspirin and maltol, showed any significant effect on the activity of antioxidant enzyme. Because accumulation may stimulate the thrombogenesis in blood, the result suggests that the induction of blood antiperoxidative activity produced by aspalatone may have beneficial effects on the thrombogenesis.
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KEYWORD
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Aspalatone(acetylsalicylic acid maltol ester), New antithrombotic agent, An-tioxidant efficacy, Rat blood
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